For hit proposal, we generally have the following considerations: 1) signal strength (sequence count, feature intensity), 2) chemotype diversity, 3) physchem properties, 4) structural relationship across different DELs and mechanism of action (signal comparison between samples). A representative hit proposal workflow is shown below.
HitGen is capable of industry leading synthesis with experienced chemists that have worked on over hundreds of projects and advanced equipment, instruments. Typically, 5 mg is offered for every compound and for up to 100 compounds, with 6~8 weeks lead time. Gram-scale of synthesis is also available as needed.
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